Could a pill replace exercise? Scientists make bold claim about new protein

Katie Ramirez
January 15, 2020

WOULD you like to lie around all day and achieve the honed, healthy body of a gym bunny, just by popping a pill?

During experiments, a team led by researchers from the University of MI found that suppressing Sestrins in flies and mice had a negative impact on how effective their exercise was; but by increasing Sestrin levels, the test subjects got some of the benefits of exercise without actually doing any. If continued tests yield similar results, MI scientists have noted that we could eventually see a pill synthesized and made available for human consumption that could supply the same benefits as a marathon session pumping iron at LA Fitness. For occasion, Sestrin might perchance well also conceivably lend a hand folks unable to work out resulting from extinct age or effectively being considerations defend their muscle groups.

"We propose that Sestrin can coordinate these biological activities by turning on or off different metabolic pathways", says physiologist Jun Hee Lee from the University of MI. He explained more issues in a release. In fact, the flies with the maxed out Sestrin didn't develop more endurance when exercised.

Taking advantage of Drosophila flies' normal instinct to climb up and out of a test tube, their collaborators from Wayne State University in Detroit developed a kind of fly treadmill. They then compared the walking and flight skills of normal flies and flies that lack the ability to make sestrin.

This normal control group of flies showed improved endurance and better flying ability after three weeks of training - but the same improvements weren't seen in the flies that had their Sestrin production inhibited.

Sestrin, which is produced naturally during exercise, was found in tests to be the reason that physical activity burns fat, builds our muscles and improves our breathing.

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In addition to these findings intriguing flies, researchers also bred a personnel of mice that had been unable to produce Sestrin. The flies given the max dose did not appear to get in any better shape after exercising, indicating that Sestrin alone effectively caused them the reach full physical potential, according to the researchers.

Pura Muñoz-Cánoves from the Pompeu Fabra University in Spain, with help from Lee, demonstrated that the protein Sestrin can help in preventing muscle atrophy in a muscle that has been immobilised for a long time, for eg if one's limb has been in a cast for a long time.

Can sestrin supplements be on the horizon?

Scientists still don't know how exercise produces Sestrin in the body, Kim said.

"Sestrins are no longer little molecules, but we are working to salvage little molecule modulators of Sestrin", Lee says.

"Here's extremely extreme for future notion and might perchance well also lead to a medicines for folk that can not exercise", Kim concludes.

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