USA announces antibody that blocks SARS-CoV-2

Grant Boone
May 21, 2020

The antibody will become the first ingredient of a developing three-part COVI-SHIELD "antibody cocktail", and could also be processed into a stand-alone therapy under the name COVI-GUARD.

U.S. biopharmaceutical company claims to have discovered an antibody that could shield the human body from the coronavirus and flush it out of a person's system within four days. SARS-CoV-2 is the virus that leads to the coronavirus, and the antibody found is likely to be effective in treating the root cause of the infection.

Among the antibodies showing neutralizing activity, one antibody stood out for its ability to completely block SARS-CoV-2 infection of healthy cells in the experiments. "There is a solution that works 100 percent", Dr. Henry Ji, founder, and CEO of Sorrento Therapeutics, told Fox News. Sorrento is better known as a gene-editing stock, with the company working on its own potential treatments in that area. COVI-SHIELD is expected to deliver a mixture of three antibodies that combined recognize three specific regions of the SARS-CoV-2 Spike protein, reports.

According to him, anti-STI-1499 "envelop virus" and makes it impossible to "cling to the cells in the human body". Each dose could potentially protect someone for as long as two months, and then they could get another shot. As a result, it surely prevents the virus attaches itself to healthy host cells, thus eliminating the chances of incubation or infection. Sorrento's multimodal, multipronged approach to fighting cancer is made possible by its extensive immuno-oncology platforms, including key assets such as fully human antibodies ("G-MAB™ library"), clinical stage immuno-cellular therapies ("CAR-T", "DAR-T"), antibody-drug conjugates ("ADCs"), and clinical stage oncolytic virus ("Seprehvir®").

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Numerous companies and universities worldwide have been exploring on finding the cure to the coronavirus, including the use of antibodies. You have already provided it. The company expects to produce up to 200,000 doses per month and seeks governmental support to increase production to meet demand.

"As soon as it is infused, that patient is now immune to the disease", SVP of Sorrento Dr. Mark Brunswick said.

The company has now applied to the US Food and Drug Administration (FDA) for permission to use antibodies.

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